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WEBINAR SERIES AT DEPARTMENT OF MOLECULAR BIOTECHNOLOGY AND HEALTHY SCIENCES
Dati principali del Corso ECM FAD
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WEBINAR SERIES AT DEPARTMENT OF MOLECULAR BIOTECHNOLOGY AND HEALTHY SCIENCES
PREMISE OF CANCER IMMUNOTHERAPY: WHERE DO WE STAND
PRIMO WEBINAR - 8 LUGLIO 2020
"Functional interplay between phosphoinositide 3-kinases (PI3K) and indoleamine 2,3-dioxygenase 1 (IDO1) in immune regulation"
Speaker: Ursula Grohmann - Dept. Exp. Medicine, University of Perugia, Italy
WEBINAR NON ACCREDITATO ECM - Il Seminario si terrà il giorno 8 luglio 2020 dalle ore 15.00 alle ore 16.00. Ad iscrizione effettuata verrà inviato via mail il link per la partecipazione all'incontro.
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gratuito
In its phosphorylated form, IDO1 acts as a signaling molecule in a pathway that induces long-lasting immunosuppressive effects via genomic mechanisms in plasmacytoid dendritic cells (pDCs). Whether the two activities, i.e., catalytic and signaling, are spatially segregated has been unclear. We found that, under conditions favoring signaling rather than enzymic activity, IDO1 switches from cytosol to early endosomes.
This event required direct interaction with and activation of class IA phosphoinositide 3-kinases (PI3Ks), which contributed to the full expression in vivo of the immunoregulatory phenotype conferred on pDCs by the IDO1 signaling pathway.
Thus IDO1’s spatial dynamics, besides accommodating the needs for short- vs long-lasting mechanisms controlling acute vs chronic inflammation, respectively, may open a completely new perspective in IDO1-based therapies.
Requisiti tecnici per la fruizione del corso:
• Connessione a Internet
• Browser web di ultima generazione
Prof. Francesco Novelli e del Comitato Organizzatore composto da Alessandra Ghigo, Laura Conti, Paola Cappello e Claudia Curcio
